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In 1903, A. Rydel and F.W. Seiffer published the use of what is now commonly known as the Rydel-Seiffer tuning fork.1 In their paper, they described an adaptation of the standard tuning fork to make it semiquantitative on an 8-point scale in measuring vibration sensing. The Rydel-Seiffer tuning fork has been used extensively over the past century and normative values have been published.2 It has also been validated with the use of more modern sensory nerve action potentials.3 Vibration threshold measurement with the Rydel-Seiffer tuning fork is therefore increasingly used in outcome measures assessing neuropathy from diverse etiologies: chemotherapy-induced peripheral neuropathy,4 Charcot-Marie-Tooth disease,5 multifocal motor neuropathy,6 and immune-mediated neuropathies.7
Footnotes
Supplemental data at Neurology.org
Author contributions: Francis B. Panosyan: concept and design, acquisition of data, analysis and interpretation of data. Joan M. Mountain: revising the manuscript for content, acquisition of data. Mary M. Reilly: analysis and interpretation of data, revising the manuscript for content. Michael E. Shy: analysis and interpretation of data, revising the manuscript for content. David N. Herrmann: analysis and interpretation of data, revising the manuscript for content, supervisor.
Study funding: Supported by NIH-RDCRN U54 (U54NS065712).
Disclosure: F. Panosyan, J. Mountain, M. Reilly, and M. Shy report no disclosures relevant to the manuscript. D. Herrmann received grant support from NINDS (U54NS065712), FARA, MDA, and has received funds for consulting or adjudication activities from Medpace, Guidepoint Global, Voyager, Inc., and LAM Therapeutics. Go to Neurology.org for full disclosures.
- Received March 9, 2016.
- Accepted in final form May 5, 2016.
- © 2016 American Academy of Neurology
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