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MRI-guided focused ultrasound (MRgFUS) is a promising, incision-free but nevertheless invasive technique to ablate deep brain targets.1 Recent studies have investigated the effectiveness and safety of MRgFUS targeting the ventrointermedius nucleus (Vim) of patients with tremor. In separate studies, 4,2 15,3 and 84 patients with essential tremor (ET) were included and followed up for 3 to 12 months after unilateral MRgFUS. The majority of the cases had a clinically meaningful reduction of contralateral hand tremor up to 90%.
Footnotes
Supplemental data at Neurology.org
Author contributions: Alfonso Fasano: drafting/revising the manuscript, study concept or design, analysis or interpretation of data, accepts responsibility for conduct of research and will give final approval, acquisition of data, study supervision. Francesco Sammartino: drafting/revising the manuscript, study concept or design, analysis or interpretation of data, accepts responsibility for conduct of research and will give final approval, acquisition of data, statistical analysis. Maheleth Llinas: drafting/revising the manuscript, analysis or interpretation of data, accepts responsibility for conduct of research and will give final approval, statistical analysis, study supervision. Andres M. Lozano: drafting/revising the manuscript, study concept or design, analysis or interpretation of data, accepts responsibility for conduct of research and will give final approval, contribution of vital reagents/tools/patients, acquisition of data, statistical analysis, study supervision, obtaining funding.
Study funding: No targeted funding reported.
Disclosure: A.M.L. is a consultant to the Focused Ultrasound Foundation and has received research support from InSightec in the past. Dr. Fasano has received grant support from the University of Toronto, the McLaughlin Centre, and the Michael J. Fox Foundation; he received speaking honoraria from UCB Pharma, Medtronic, Boston Scientific, AbbVie, Novartis, Chiesi Pharmaceutical, and TEVA; he is on an advisory board for AbbVie and provided consultancies for UCB Pharma, Medtronic, Boston Scientific, and AbbVie. Ms. Llinas and Dr. Sammartino report no disclosures. Dr. Lozano holds stock ownership in medically related fields (Functional Neuromodulation) and provided consultancies for Medtronic St. Jude, Boston Scientific, and InSightec. Go to Neurology.org for full disclosures.
- Received January 8, 2016.
- Accepted in final form May 3, 2016.
- © 2016 American Academy of Neurology
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