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Chronic pain syndrome is a complex disorder that includes not only the presence of spontaneous pain and exaggerated responses to painful and nonpainful stimuli but also the development of a negative affective, motivational, and cognitive state and the persistent desire to eliminate pain. Recent evidence indicates that chronic pain shares basic mechanisms with reward-based learning and drug addiction1–3 and that the transition from acute to chronic pain reflects functional reorganization of this reward/motivational circuitry.4
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- © 2016 American Academy of Neurology
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