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Editors' Note: Commenting on “Midlife personality and risk of Alzheimer disease and distress: A 38-year follow-up,” Caselli pointed out a discrepancy in the prevalence of the APOE ε4 allele between the current study and historical data. This was actually due to an error in one of the article's tables, rather than true difference in prevalence, and was subsequently corrected by Neurology®. Commenting on the same article, Coon suggests that socioeconomic status may have been an important but neglected confounder. Authors Johansson et al. acknowledge the deficiency in socioeconomic data in their cohort, which made that analysis impossible.—Chafic Karam, MD, and Robert C. Griggs, MD
Johansson et al.1 described the influence of personality features and long-standing distress on the risk of Alzheimer disease (AD) dementia, which remained significant after controlling for possession of the APOE ε4 allele in a subset of 306 women with APOE …
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