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There has been intense scrutiny of the failure to translate preclinical studies in stroke. By contrast, much less attention has been directed to asking how treatments get from an early-phase to late-phase clinical trial. While much of the focus has been in stroke, a similar failure to translate has been all too common in other neurologic disorders.
Footnotes
The sentiment in the title is attributed to the great English statistician, George E.P. Box (Box GEP, Draper NR. Empirical Model-Building and Response Surfaces. Hoboken, NJ: John Wiley & Sons, Inc.; 1987).
Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the editorial.
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- © 2015 American Academy of Neurology
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