This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
Diagnostic parsimony and a focus on single genes may encourage overinterpretation of the clinical import of specific genetic variants. With conditions as complex and common as migraine, there are additional confounding factors: clinical and genetic heterogeneity and incomplete penetrance. Pelzer et al.1 re-examined a family with both hemiplegic migraine (FHM) and benign familial infantile seizures (BFIS) previously attributed to a mutation in the FHM2 gene ATP1A2.2 The recent discovery of mutations in the proline-rich transmembrane protein 2 (PRRT2) gene primarily in familial paroxysmal kinesigenic dyskinesia but also in other childhood-onset episodic disorders (including FHM and BFIS) prompted the authors to re-examine this family to uncover a new mutation in PRRT2.
Footnotes
Study funding: No targeted funding reported.
Disclosure: J.C. Jen receives funding support from the FDA and serves on the editorial boards of Experimental Brain Research and Frontiers in Neurology.
- © 2014 American Academy of Neurology
AAN Members
We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.
AAN Non-Member Subscribers
Purchase access
Letters: Rapid online correspondence
REQUIREMENTS
If you are uploading a letter concerning an article:
You must have updated your disclosures within six months: http://submit.neurology.org
Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.
Submission specifications:
- Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
- Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
- Submit only on articles published within 6 months of issue date.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- Submitted comments are subject to editing and editor review prior to posting.
You May Also be Interested in
Anti-Hu Antibodies in Patients With Neurologic Side Effects of Immune Checkpoint Inhibitors
Dr. Josep Dalmau and Dr. Mar Guasp