Comment: EEGs not likely helpful for behavioral assessments in Smith-Lemli-Opitz
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Neurologists' interpretations that a routine EEG shows interictal epileptiform discharges (IEDs) have high variability and low sensitivity in cohorts of idiopathic epilepsies.1 However, given the wide availability of EEG and the heterogeneous nature and observational criteria for behavioral diagnoses, identifying brain-based biomarkers such as IEDs could be helpful.
Footnotes
Study funding: No targeted funding reported.
Disclosure: D. Gilbert has received honoraria from the Tourette Syndrome Association/Centers for Disease Control and Prevention and the American Academy of Pediatrics; serves on the medical advisory board for the Tourette Syndrome Association; and has received book royalty from Elsevier. Dr. Gilbert has received research support (for Tourette Syndrome, ADHD) from the NIH (NIMH R01 MH092520, NIMH R01 MH081854), from the Cincinnati Children's Hospital Research Foundation, the University of Cincinnati, the Tourette Syndrome Association, Otsuka Pharmaceuticals (clinical trial, Tourette Syndrome), Ecopipam Pharmaceuticals (clinical trial, Tourette Syndrome), and AstraZeneca (clinical trial, Tourette Syndrome). Go to Neurology.org for full disclosures.
- © 2014 American Academy of Neurology
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