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Thomas Henry Huxley, known as “Darwin's bulldog” for his staunch advocacy of the theory of evolution, is credited with the following statement: “The great tragedy of science—the slaying of a beautiful hypothesis by an ugly fact.” The study by Caniglia et al.1 in this issue of Neurology® demonstrating that HIV-infected individuals treated with antiretroviral regimens exhibiting better CNS penetration had higher rates of HIV dementia is perhaps the “ugly fact” that might slay a beautiful and widely touted hypothesis. The finding is not only unexpected, but counterintuitive.
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- © 2014 American Academy of Neurology
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