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In mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS), a multisystem mitochondrial disorder, gastrointestinal involvement is frequent with dysphagia, chronic diarrhea, anorexia, abdominal pain, delayed gastric emptying, and paralytic, often intractable, ileus.1 In this article, we report a patient with chronic gastrointestinal dysmotility and acute refractory intestinal pseudo-obstruction responsive to prucalopride.
Footnotes
Author contributions: Drafting/revising the manuscript for content, including medical writing for content: Dr. Primiano, Dr. Plantone, Dr. Servidei. Study concept or design: Dr. Primiano, Dr. Plantone, Dr. Forte, Dr. Sauchelli, Dr. Scaldaferri, Dr. Gasbarrini, Dr. Servidei. Analysis or interpretation of data: Dr. Primiano, Dr. Plantone, Dr. Forte, Dr. Sauchelli, Dr. Scaldaferri, Dr. Gasbarrini, Dr. Servidei. Acquisition of data: Dr. Primiano, Dr. Plantone, Dr. Forte, Dr. Sauchelli, Dr. Scaldaferri, Dr. Gasbarrini, Dr. Servidei. Study supervision or coordination: Dr. Primiano, Dr. Plantone, Dr. Servidei.
Study funding: No targeted funding reported.
Disclosure: The authors report no disclosures relevant to the manuscript. Go to Neurology.org for full disclosures.
- Received November 28, 2013.
- Accepted in final form February 24, 2014.
- © 2014 American Academy of Neurology
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