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Identifying autoantibodies and their respective targets as biomarkers for neuroinflammatory disorders is a long-standing and highly productive activity that has resulted in substantial improvements in the diagnosis and clinical management of a number of neurologic diseases, the archetypical example being the identification of anti-acetylcholine receptor (AChR) autoantibodies as a pathogenic entity in myasthenia gravis. Similarly, the discovery in 2005 that aquaporin-4 (AQP4)–specific autoantibodies provide a biomarker …
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