Serum adipocyte fatty acid–binding protein associated with ischemic stroke and early death
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Abstract
Objective: Adipocyte fatty acid–binding protein (A-FABP) is an adipokine shown to have adverse metabolic and proinflammatory effects, and contributes to atherosclerosis in mice. However, its role in cardiovascular diseases in humans remains to be established. In this case-control study, we investigated the association of serum A-FABP with ischemic stroke, and examined its association with early mortality.
Methods: Serum A-FABP was measured, using ELISA, in 306 subjects with acute ischemic stroke and 306 age-, sex-, and body mass index–matched controls. All controls were free of cardiovascular diseases. Serum A-FABP was also measured in another 60 ischemic stroke subjects who died within 3 months of acute stroke.
Results: Serum A-FABP was higher in subjects with ischemic stroke as compared to controls (19.6 ng/mL [14.3–28.4 ng/mL] vs 15.2 ng/mL [10.6–23.6 ng/mL] in men and 32.4 ng/mL [24.5–45.7 ng/mL] vs 22.0 ng/mL [14.3–34.0 ng/mL] in women, stroke vs control, p < 0.001). On logistic regression analyses with the model including hypertension, diabetes, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglyceride, lipid-lowering treatment, smoking, and A-FABP, serum A-FABP was independently associated with stroke (odds ratio 2.10, 95% confidence interval 1.50–2.94, p < 0.001), and the associations of A-FABP with ischemic stroke were additive to conventional risk factors, as demonstrated on likelihood ratio tests (p < 0.001). Furthermore, high serum A-FABP was associated with increased 3-month mortality in ischemic stroke subjects (odds ratio 2.65, 95% confidence interval 1.18–5.96, p = 0.018), independent of age and NIH Stroke Scale score.
Conclusions: Serum A-FABP was significantly associated with ischemic stroke in our case-control study, and may serve as a useful prognostic indicator for early mortality.
Footnotes
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Study funding: Supported by the Hong Kong Research Grant Council (GRF HKU7590/06M and CRF HKU 2/07M) and the Stanley Ho Alumni Challenge (first and second years) for “Clinical and experimental stroke research.”
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Editorial, page 1954
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- A-FABP
- adipocyte fatty acid–binding protein
- BMI
- body mass index
- CI
- confidence interval
- CVD
- cardiovascular disease
- DM
- diabetes mellitus
- HDL
- high-density lipoprotein
- LDL
- low-density lipoprotein
- NIHSS
- NIH Stroke Scale
- OR
- odds ratio
- SBP
- systolic blood pressure.
- Received June 18, 2010.
- Accepted December 13, 2010.
- Copyright © 2011 by AAN Enterprises, Inc.
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