Adipocyte fatty acid–binding protein and ischemic stroke
Another brick in the wall?
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With our seeming inability to prevent the current obesity epidemic, the task of mitigating the associated burden of disease becomes of greater importance. Cerebrovascular diseases form an important component of the disease burden of obesity; however, the molecular mechanisms that underlie this association remain only crudely described. Furthermore, our ability to identify those obese individuals at greatest risk is limited. Factors that have shown promise as predictors of myocardial infarction and atherosclerosis represent plausible candidates for the study of ischemic stroke due to etiologic overlap.
One such candidate, adipocyte fatty acid–binding protein (A-FABP, also known as FABP4 or aP2), is an intracellular lipid-binding protein that is highly expressed in adipocytes, and involved in inflammation, glucose, and lipid metabolism.1 Circulating levels of A-FABP have been linked to the severity of atherosclerosis and cardiovascular disease events.2,–,4 Macrophages in human atherosclerotic lesions express A-FABP. A-FABP expression may influence vulnerability to plaque rupture,4 possibly via regulation of macrophage peroxisome proliferator-activated receptor gamma activity, inflammatory pathways involving IκB kinase and NF-κB, and expression of cyclooxygenase-2 and inducible nitric oxide synthase,5 suggesting this molecule may play an important biological …
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