Fluctuating concepts of childhood absence epilepsy
Citation Manager Formats
Make Comment
See Comments
This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
Childhood absence epilepsy (CAE) appears not to be benign. Generations of pediatric neurologists have considered this form of childhood epilepsy to be less severe, since intellectual function is usually not severely affected. Over the past year, however, this common childhood epilepsy has received increasing attention, with results suggesting a more complex picture. The complicated relationship of seizures and attentional impairment in CAE is just one example of the broader behavioral, cognitive, and linguistic difficulties in children with CAE.
In this issue of Neurology®, Bai et al.1 investigate functional network activity as a surrogate for executive functions. They demonstrate interictal abnormalities in resting state blood oxygenation level–dependent (BOLD) functional connectivity (fc-MRI) datasets from children with CAE, compared to typically developing children. Strikingly, the difference is one of increased connectivity between homotopic areas of lateral prefrontal cortex. They show, with concurrent EEG-fMRI in the most rigorous manner possible, that the often frequent absence seizures themselves did not overtly influence the finding of increased connectivity. A finding of increased resting state functional connectivity is relatively rare in the rapidly expanding literature describing resting state fc-MRI in neurologic disease. Most studies across neurologic disease describe decreased functional connectivity, which is …
AAN Members
We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.
AAN Non-Member Subscribers
Purchase access
For assistance, please contact:
AAN Members (800) 879-1960 or (612) 928-6000 (International)
Non-AAN Member subscribers (800) 638-3030 or (301) 223-2300 option 3, select 1 (international)
Sign Up
Information on how to subscribe to Neurology and Neurology: Clinical Practice can be found here
Purchase
Individual access to articles is available through the Add to Cart option on the article page. Access for 1 day (from the computer you are currently using) is US$ 39.00. Pay-per-view content is for the use of the payee only, and content may not be further distributed by print or electronic means. The payee may view, download, and/or print the article for his/her personal, scholarly, research, and educational use. Distributing copies (electronic or otherwise) of the article is not allowed.
Letters: Rapid online correspondence
REQUIREMENTS
You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.
Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.
Submission specifications:
- Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
- Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
- Submit only on articles published within 6 months of issue date.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- Submitted comments are subject to editing and editor review prior to posting.
You May Also be Interested in
Hastening the Diagnosis of Amyotrophic Lateral Sclerosis
Dr. Brian Callaghan and Dr. Kellen Quigg
► Watch
Related Articles
Topics Discussed
Alert Me
Recommended articles
-
Articles
The frontal lobe in absence epilepsyEEG-fMRI findingsP.W. Carney, R.A.J. Masterton, D. Flanagan et al.Neurology, March 28, 2012 -
Articles
The core network in absence epilepsyDifferences in cortical and thalamic BOLD responseP.W. Carney, R.A.J. Masterton, A.S. Harvey et al.Neurology, August 11, 2010 -
Articles
EEG-fMRIAdding to standard evaluations of patients with nonlesional frontal lobe epilepsyF. Moeller, L. Tyvaert, D. K. Nguyen et al.Neurology, December 07, 2009 -
Articles
Cortical/subcortical BOLD changes associated with epileptic dischargesAn EEG-fMRI study at 3 TPaolo Federico, John S. Archer, David F. Abbott et al.Neurology, April 11, 2005