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The connection between the AAG/AAG and AGG/AGG haplotypes of the 3 single nucleotide polymorphisms (SNPs) (−2578C/A, −1154G/A, and −634G/C) of the vascular endothelial growth factor (VEGF) gene and sporadic amyotrophic lateral sclerosis (sALS) was documented in some, but not all populations.1 It was also shown that plasma VEGF levels in patients with sALS were significantly lower than in the controls.1 A recent meta-analysis comprising 7,082 participants did not confirm the association between risk haplotypes and sALS.2 Other studies did not confirm an association between plasma or serum VEGF levels and the risk of sALS.3,–,5 We studied the significance of the AAG/AAG and AGG/AGG haplotypes of the 3 SNPs of the VEGF gene as well as the significance of plasma VEGF levels in Polish patients with sALS.
Methods.
We included 271 unrelated patients with definite or probable sALS (El Escorial Criteria) admitted to the MND Clinic, Jagiellonian University, Poland. The controls consisted of 464 age- and gender-matched …
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