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To the Editor:
I read with interest the case illustration by Surov et al.1 presenting impressive MR images of bilateral masses along peripheral nerves. Due to the large number of tumors, the authors termed it “schwannomatosis.”
These masses occurred in this patient apparently with neurofibromatosis type 1 (NF-1) also known as von Recklinghausen disease and fulfilling diagnostic criteria for NF-1 because the patient had multiple cutaneous neurofibromas and café-au-lait spots.
NF-1 is an autosomal dominant disorder caused by mutations of the NF-1 gene on chromosome 17q11.2. The term von Recklinghausen disease is associated with NF-1 and should not be used with other types of neurofibromatosis. Characteristic nervous system neoplasms include neurofibromas, malignant peripheral nerve sheath tumors, and gliomas. Schwannomas do not belong to this group.2
Neurofibromatosis type 2 (NF-2) is a clinically and genetically different disease caused by …
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