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Restless legs syndrome (RLS) is characterized by diurnal restless discomfort, usually affecting the lower extremities, often associated with periodic limb movements in sleep. It is among the most prevalent neurologic syndromes and yet remains a puzzle in many respects; even its prevalence has been a matter of debate, with estimates ranging from 1 to 20%.1,2 RLS may be classified as primary or secondary with secondary causes including myelopathy, uremia, iron deficiency, and Parkinson disease. Peripheral neuropathy has been cited as a potential cause of RLS, though this association has been controversial, with prevalence estimates of RLS in patients with peripheral neuropathy ranging from 5 to 54%.
In the current issue of Neurology®, Hattan et al.3 report the results of a prospective, case-control study examining the prevalence of RLS …
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