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Aberrantly spliced α-dystrobrevin alters α-syntrophin binding in myotonic dystrophy type 1
α-Dystrobrevin has been added to the list of misspliced mRNAs observed in myotonic dystrophy. This paper suggests that the aberrantly spliced dystrobrevin with altered syntrophin binding may influence signaling in muscle cells and may potentially be relevant to the muscle wasting in myotonic dystrophy.
See p. 677
Evidence for linkage of restless legs syndrome to chromosome 9p: Are there two distinct loci?
Restless legs syndrome (RLS) is a common movement disorder affecting individuals of all ages. Although a high familial aggregation exists, …
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