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Trajectories of brain loss in aging and the development of cognitive impairment
Using longitudinal measurement of MRI volumes, the authors show that presymptomatic brain atrophy develops at a faster rate in those developing mild cognitive impairment at least a decade prior to clinical symptoms. These differential rates of preclinical atrophy suggest that brain-sparing therapies will need to be applied years before symptom onset.
See p. 828; Editorial, p. 284
Association of serum lipid indices with large artery atherosclerotic stroke
This study found that elevated levels of serum …
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