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To the Editor:
We are intrigued by the additional evidence on the protective effect of premorbid antiplatelet use in patients with stroke reported by Sanossian et al.1
Although the study showed that premorbid antiplatelet drugs had a protective effect on short-term outcome, the authors did not provide sufficient background to analyze this effect. Rankin score was assessed at discharge but this is a vague timepoint. It was recently shown that some patients with stroke had functional deterioration after early recovery2 and the highest risk of occurrence of stroke after TIA or minor stroke is within the first several days.3 If the time to assess Rankin score is too early, a confounding effect is unclear due to the subgroup of unstable patients.
In addition, any medications used after stroke were …
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