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Atrial fibrillation is a risk factor for ischemic stroke.1 Hyperthyroidism is a cause of atrial fibrillation. Subclinical hyperthyroidism, also associated with atrial fibrillation, may result from excess thyroid replacement therapy.2,3 However, it is unclear whether thyroid replacement therapy is a risk factor for atrial fibrillation in patients with acute ischemic stroke. In this case-control study, we sought to determine the association between thyroid replacement therapy and atrial fibrillation in patients presenting with ischemic stroke.
Methods.
The study protocol was approved by the local Institutional Research Board at Stanford University Medical Center. We identified consecutive patients with ischemic stroke with atrial fibrillation (cases) and without atrial fibrillation (controls) admitted to the Stanford Stroke Center between 1996 and 2004 through a local stroke registry database. The stroke registry (3,276 subjects) includes patients presenting with ischemic stroke, TIA, hemorrhagic stroke, and patients in whom stroke was suspected but …
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