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April 25, 2006; 66 (8) Brief Communications

Magnetic source imaging localizes epileptogenic zone in children with tuberous sclerosis complex

J. Y. Wu, W. W. Sutherling, S. Koh, N. Salamon, R. Jonas, S. Yudovin, R. Sankar, W. D. Shields, G. W. Mathern
First published April 24, 2006, DOI: https://doi.org/10.1212/01.wnl.0000208412.59491.9b
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Abstract

The authors assessed whether magnetoencephalography/magnetic source imaging (MEG/MSI) identified epileptogenic zones in patients with tuberous sclerosis complex (TSC). In six TSC children with focal seizures, ictal video-EEG predicted the region of resection with 56% sensitivity, 80% specificity, and 77% accuracy (p = 0.02), whereas interictal MEG/MSI fared better (100%, 94%, and 95%, respectively; p < 0.0001). Interictal MEG/MSI seems to identify epileptogenic zones more accurately in children with TSC and focal intractable epilepsy.

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