The first organ transplant from a brain-dead donor
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To the Editor:
I read with interest the article by Machado.1 The author asserts that my article on the Harvard criteria failed to discuss the Ciba document and Wertheimer's paper.2 It is true that the study concentrated on the committee's workings and the role of the neurologists.
A comprehensive history of the development of brain death criteria is in a book chapter with earlier descriptions of brain death, including Wertheimer and an even earlier document by Lofstedt and Von Reis.3 It includes the disclosures of Alexandre presented anew in Machado's paper.3 The far less detailed criteria of surgeon Alexandre were actually modified from the criteria of the neurologists Mollaret and Goulon. Alexandre's criteria, the generally negative reception by the attendees and virtual unanimous disinterest to use them, have also been discussed.4
Machado also doubts the originality of the Harvard Criteria of brain death. Some committee members attended an earlier Ciba symposium that discussed brain death criteria by Alexandre …
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