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Abstract
The use of rapid infusion of large-volume cold saline (CS) as an adjunctive therapy for treating refractory fever in nine patients is reported. A decline in temperature (39.2 ± 0.3 vs 37.1 ± 1.2 °C, p = 0.006) at 2 hours and fever burden (97.3 ± 343.8 vs 734.3 ± 422.3 °C*min, p = 0.02) at 12 hours was noted after CS bolus. Rapid infusion of large-volume CS may be used as an adjunct for inducing normothermia in refractory febrile patients.
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