This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
Human T-cell lymphotrophic virus (HTLV)-I causes tropical spastic paraparesis/HTLV-I associated myelopathy (HAM/TSP) and may have other neurologic manifestations such as isolated peripheral neuropathy.1 An HTLV-I-associated ALS-like syndrome (ALS-S) has been rarely reported.2 We now describe the features of ALS-S in a cohort of HTLV-I infected individuals.
Methods.
From May 1992 to September 2004, 606 HTLV-I infected individuals who fulfilled international criteria for serologic positivity at both ELISA and Western blot tests were admitted to our institution. The clinical diagnosis of HAM/TSP was based on World Health Organization guidelines,3 which basically define it as a chronic, slowly progressive spastic paraparesis, with bladder disturbances, sensory symptoms, and low back pain. EMG of at least three limbs and nerve conduction studies were performed. Diagnosis of ALS-S was made by El Escorial criteria.4 Informed consent was obtained from all individuals.
Results.
Of 606 infected individuals, 259 had some neurologic abnormality; 169 had HAM/TSP (65.2%) and 90 (34.7%) had other neurologic abnormalities. Five patients …
AAN Members
We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.
AAN Non-Member Subscribers
Purchase access
Letters: Rapid online correspondence
REQUIREMENTS
You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.
Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.
Submission specifications:
- Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
- Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
- Submit only on articles published within 6 months of issue date.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- Submitted comments are subject to editing and editor review prior to posting.
You May Also be Interested in
Hastening the Diagnosis of Amyotrophic Lateral Sclerosis
Dr. Brian Callaghan and Dr. Kellen Quigg