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To the Editor:
The minimally conscious state (MCS) is considered a transitional phase in the partial recovery of self-awareness or environmental-awareness from the vegetative state (VS). This recognition highlights the crucial role of pathophysiology in elucidating the generation of consciousness in these cases.1
The patient described by Laureys et al. showed context-dependent higher-order auditory processing. The authors previously reported that in the VS, auditory stimulation activates primary auditory cortices but not higher-order associative areas from which they have been disconnected. Their work revealed that functional connectivity between primary and higher-order associative cortices areas can be partially preserved in MCS although disconnected in VS.2
In the original description of the apallic syndrome, extensive bilateral damage …
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