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Investigators are studying the natural history of and considering clinical trials for Charcot–Marie–Tooth disease (CMT). It is important to determine how health-related quality of life (QOL) affects these chronic neuropathies. Vinci et al. have utilized the Medical Outcome Study Short Form-36 (SF-36) Quality of Life scale to evaluate 121 patients with CMT disease.1 The SF-36 consists of eight subscales that can be combined into Physical Function (PCS-36) and Mental Function (MHC-36) scores. Because the SF-36 is a generic as opposed to a disease-specific QOL measure, it allows comparison of CMT patients with the population at large, as well as with patients with other disorders.2 As a result, Vinci et al. were able to show that patients with CMT as a group have significantly lower PCS-36 and MHC-36 scores than the Italian population as a whole. In addition, they found differences between older and younger patients, men and women, and patients in and out of work but not between patients with demyelinating or axonal forms of CMT.
Readers may be forgiven for thinking that some of the findings in the article are intuitive because one would expect QOL to be impaired in …
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