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Susceptibility-weighted sequences may improve our understanding of the pathophysiology of acute cerebral ischemia.1–4 At the acute stage of ischemic stroke, a signal loss, attributed to intravascular deoxygenation, has been identified with T2*-weighted gradient echo (GRE) MRI along the course of leptomeningeal vessels.5 We sought to detect any difference between clinical and MRI parameters according to the presence of this imaging feature.
Methods.
Consecutive patients with acute (<6 hours) hemispheric stroke were recruited between March 2002 and September 2003. Neurologic impairment was assessed using the NIH Stroke Scale (NIHSS) score.
MRI was performed with a 1.5 T imager (Siemens Vision, Erlangen, Germany). MRI protocol included6 the following: three-dimensional time-of-flight MR angiography (MRA); T2*-weighted GRE sequence; diffusion-weighted imaging (DWI); and perfusion-weighted MRI (PWI) with an echo-planar imaging sequence, using the bolus passage of contrast agent.
The abnormal visualization of leptomeningeal vessels (AVLV) was defined at baseline T2*-weighted GRE sequence as a serpiginous signal loss along the course of the juxtacortical vessels5 (figure). The …
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