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To the Editor:
We agree with Pengiran Tengah et al.1 that gluten sensitivity is not etiologically linked to multiple sclerosis (MS). We screened 100 patients with relapsing-remitting, secondary progressive MS, or both, and found the prevalence of antigliadin antibodies (AGA) to be 10%; the same as in the healthy population (1,200 healthy volunteers, prevalence of 12.5%).2 Involvement of the white matter of the brain and spinal cord in the context of gluten sensitivity has been reported.3 However, the MRI changes in those cases were different than seen in MS, being more peripherally situated and often confluent. Pengiran Tengah et al. describe two patients with apparent “atypical” MS-like illnesses both having ataxia in addition to other neurological deficits. We encountered five patients labeled as having primary progressive or atypical MS-like illnesses who had gluten sensitivity. The predominant feature was ataxia but other focal neurologic deficits …
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