A fetal circle of Willis is associated with a decreased deep white matter lesion load
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To the Editor:
We read the article by van der Grond et al.1 with great interest. We also examined healthy adults to determine whether fetal patterns are associated with risk factors of cerebrovascular disease and white matter lesions (WMLs).
Our study included 3,780 subjects (2,600 men and 1,180 women) who had examinations including brain MRI and 3-D time-of-flight MR angiography (1.5 T; Hitachi Medical, Japan) between September 2003 and October 2004 at the PL Tokyo Health Care Center. Mean age (SD) of the subjects was 51.8 (11.3) years. Frequency of fetal posterior configuration of circle of Willis, deep and periventricular WMLs, and cerebrovascular risk factors were determined.2 Those data were analyzed and the two groups were compared for …
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