Association of genetic loci: Replication or not, that is the question
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To the Editor:
We agree with Ott1 that associations need substantiating replications to avoid exploring false positives. We welcome, noting their careful nature and interpretations, partial and exact replication attempts2,3 of our initial findings.
We did not, as stated,1 study five ABCB1 SNPs, reporting association for only one. We studied only C3435T.
For the near future, with relatively small sample sizes, association studies can and should be guided by biology. The association we reported was modest, as we have emphasized.4 It would carry …
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