This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
MRI plays a critical role in diagnosing and monitoring cerebral changes in demyelinating disorders such as multiple sclerosis (MS) and adrenoleukodystrophy (ALD). Conventional T2-weighted and gadolinium-enhanced MRI have established utility for visualizing inflammatory demyelinating lesions in MS and ALD. However, characterization of subtle changes that escape detection by these modalities requires quantitative MR techniques such as magnetization transfer (MT) imaging. Cerebral MT imaging has a recognized role in demyelinating disease,1 but spinal cord imaging is complicated by the small cord size, interference from surrounding structures, and contamination by CSF pulsation artifacts. Because of these limitations, the potential of MT imaging for evaluation of demyelinating cord lesions remains largely unrealized.
Compared with MS, relatively little is known about the degree of spinal cord involvement in …
AAN Members
We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.
AAN Non-Member Subscribers
Purchase access
Letters: Rapid online correspondence
REQUIREMENTS
You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.
Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.
Submission specifications:
- Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
- Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
- Submit only on articles published within 6 months of issue date.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- Submitted comments are subject to editing and editor review prior to posting.
You May Also be Interested in
Alert Me
Recommended articles
A conventional and magnetization transfer MRI study of the cervical cord in patients with MS
Comparison of MS clinical phenotypes using conventional and magnetization transfer MRI
A magnetization transfer histogram study of normal-appearing brain tissue in MS
MRI and magnetization transfer imaging changes in the brain and cervical cord of patients with Devic’s neuromyelitis optica