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Abstract
After generic phenytoin (PHT) was marketed, the authors identified eight adult patients (ages 34 to 49) whose seizures increased enough to require intervention after switching to generic PHT. The mean total PHT concentration on brand (before generic) was 17.7 ± 5.3 mg/L, decreased to 12.5 ± 2.7 mg/L with generic, and increased to 17.8 ± 3.9 mg/L after brand was re-introduced. Brand and generic PHT do not yield equivalent concentrations in some patients and substitution should not be permitted without physician notification.
- Received January 21, 2004.
- Accepted June 17, 2004.
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Letters: Rapid online correspondence
- Reply to Jefferys, Sherry, Rackley, and Stetz
- Lower phenytoin serum levels in persons switched from brand to generic phenytoin
- Lower phenytoin serum levels in persons switched from brand to generic phenytoin
- Lower phenytoin serum levels in persons switched from brand to generic phenytoin
- Lower phenytoin serum levels in persons switched from brand to generic phenytoin
- Reply to Wiberg
- Lower phenytoin serum levels in persons switched from brand to generic phenytoin
- Editors' Response
- Reply to Perron
- Lower phenytoin serum levels in persons switched from brand to generic phenytoin
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