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Dengue virus (DV) belongs to the family Flaviviridae, and its infection is characterized by dengue fever, dengue hemorrhagic fever, and dengue shock syndrome. Some flaviviruses, such as Japanese encephalitis, St. Louis encephalitis, Murray Valley encephalitis, and West Nile viruses, have the common feature of neurovirulence in the human CNS, including poliomyelitis-like syndrome.1 We report a patient with dengue fever who developed gray matter myelitis.
Case report.
A 42-year-old Japanese man working in Indonesia was admitted to a local hospital because of fever (38° C). Three days after admission, he had weakness in both legs and retained urine, and he was transferred to Singapore General Hospital. On admission, he was febrile and had a generalized macular rash. There was flaccid paralysis of the lower limbs with absent knee and ankle jerks. Sensation to pinprick was decreased below T6 segment. Laboratory examination revealed thrombocytopenia. Results of CSF examination were as follows: cells, 201/mm3 (mononuclear cell dominant); glucose, 1.6 mmol/L; and protein, 100 …
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