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A number of acquired and hereditary prothrombotic states are important risk factors for childhood ischemic stroke.1 Screening for antiphospholipid syndrome (APS) is a routine component of the evaluation of a child with an arterial ischemic stroke, and a positive result often compels us to treat that child with an antithrombotic agent. Although we use such screening to guide our management, how useful is it in predicting a child’s risk of a recurrent stroke?
Previous studies in children have looked for a relationship between APS and first-time ischemic stroke. A large Canadian series found positive anticardiolipin antibodies (aCL), a marker for APS, in 33% of 92 children with arterial ischemic stroke or sinovenous thrombosis.2 A small number of …
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