This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
In this issue of Neurology, two articles evaluate treatment options for patients who had a stroke at least 2 years before the study. The topic and rationale for each study are remarkably different, but both demonstrate cortical plasticity even long after acute stroke.1,2⇓ In both articles, plasticity in the affected and the contralateral hemisphere was assessed by means of transcranial magnetic stimulation (TMS).
The leading theory of cortical plasticity is that changes in long-term potentiation (LTP)3 confer persistent changes in synaptic efficacy.4 Two different forms of LTP have been postulated: it can occur conditionally at an input to a postsynaptic cell 1) by concomitant or synchronous activation of another input to the same cell4 or 2) by a concomitant or synchronous postsynaptic depolarization.5 This model provides the basic rationale to synchronously pair low-frequency peripheral stimulation of somatosensory afferents with central TMS to induce motor cortical plasticity.6 Based …
AAN Members
We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.
AAN Non-Member Subscribers
Purchase access
Letters: Rapid online correspondence
REQUIREMENTS
You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.
Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.
Submission specifications:
- Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
- Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
- Submit only on articles published within 6 months of issue date.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- Submitted comments are subject to editing and editor review prior to posting.
You May Also be Interested in
Efficacy of Ubrogepant in the Acute Treatment of Migraine With Mild Pain vs Moderate or Severe Pain
Dr. Kathleen Digre and Dr. Kendra Pham