EDTA-dependent pseudothrombocytopenia induced by valproic acid
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Pseudothrombocytopenia is a falsely low platelet count due to platelet clumping that occurs in anticoagulated blood at room temperature.1,2⇓ Automatic analyzers therefore yield falsely low counts because they cannot count platelet clumps correctly. Pseudothrombocytopenia results when antiplatelet autoantibodies bind to platelet surface glycoproteins that are modified or exposed by the combined action of anticoagulant and low temperature.2 This occurs most often in blood samples anticoagulated with ethylenediaminetetra-acetic acid (EDTA), although citrate, oxalate, and heparin have also been implicated. Its frequency was estimated to be 0.09 to 0.13%. However, other factors, including drugs, may also be involved.
Case report.
A 1-year 9-month-old Japanese girl was born without any complications. Family history was unremarkable. She developed normally until 1 year 2 months of …
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