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Tardive dyskinesias (TD) from antipsychotic medications have no clearly effective treatment. We present a patient with TD whose dyskinesias resolved with levetiracetam therapy. The agent may have an antidyskinetic effect through calcium channel blockade in the striatum.
Case report.
A 60-year-old woman with chronic depression and borderline personality disorder presented with a 3-month history of abnormal movements of the tongue, mouth, and hands.
Five months earlier, adjunctive antidepressant treatment with lithium carbonate (300 mg per day) was discontinued after 10 years because of improvement in depression. Dyskinesias began 4 weeks later and progressed to subjective maximum within 1 month. Vitamin E (1600 IU per day) was administered for 2 months without effect. A 1-month trial of haloperidol (5 mg per day) 4 years earlier produced identical movements that resolved completely upon discontinuation of haloperidol.
Medical and family history were negative for movement disorders (including dyskinesias) or other …
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