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. . . It is of use, from time to time, to take stock, so to speak, of our knowledge of a particular disease, to see exactly where we stand in regard to it, to inquire to what conclusion the accumulated facts seem to point, and to ascertain in what direction we may look for fruitful investigations in the future. . . I propose to do this in the case of that most interesting disease known as ulcerative endocarditis. . . .William Osler, February 26, 18851
The most common complications of infectious endocarditis (IE) are heart failure, peripheral embolism, neurologic disorders, sepsis, acute renal failure, metastatic abscesses, and mycotic aneurysms.2 The most common neurologic disorder is stroke, followed by encephalopathy, retinal emboli, mycotic aneurysm, abscess, meningitis, and seizures.3,4⇓ In this issue of Neurology, Anderson et al.5 studied 707 patients with IE and found strokes in 10%. In other reports, stroke rate in patients …
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