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To the Editor:
We read with interest the recent article by Sorenson et al.,1 which extended the previous surveys on the epidemiology of amyotrophic lateral sclerosis in Rochester, Minnesota.2 The authors utilized the well-known Rochester Epidemiologic Project to identify all subjects resident in Olmsted County diagnosed with ALS between 1925 and 1998. Interestingly, they found that the incidence rates of ALS did not significantly change during the examined period, and the mean annual incidence rate was similar to that found in recent studies based on epidemiological registers in Europe,3,4⇓ confirming the idea of an uniform distribution of ALS in western countries.
A previous study performed in the same area in the period 1925–1984 found a progressive increase of age-specific ALS incidence rates with advancing age.2 Although not confirmed in other studies, this observation has been one of the most powerful indications of the neurodegenerative nature of ALS. Sorenson et al.1 now found that extending the data to the two …
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