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To the Editor:
I read with interest the article by Squitti et al.1 referring to elevated serum copper levels in AD. The copper levels referred to in the article as being above (16 umol/L) are within the usual reference range of 10–22 umol/L at laboratories performing analyses of serum copper levels.2 It appears that there are higher concentrations of copper in patients with AD than in healthy controls; however, the levels referred to are still within the usual reference range for copper levels in plasma.
Apparently, total copper levels including ceruloplasmin bound levels were being referred to. A prior study by Snaedal et al.3 noted copper and ceruloplasmin concentration in plasma in AD patients were not significantly different from healthy age and gender-matched controls; however, ceruloplasmin oxidative activity in …
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