Amyloid beta 1-42 and tau in cerebrospinal fluid after severe traumatic brain injury

Abstract

Objective: To determine whether CSF amyloid beta 1-42 (Aβ-42) and tau have predictive value for prognosis after head injury.

Methods: CSF samples were collected from 29 patients with severe head trauma between 1 and 284 days post-trauma. Aβ-42 and tau levels were measured using sandwich ELISA techniques and compared with CSF levels in patients with cognitive disorders and headache.

Results: At all time points, concentrations of Aβ-42 were significantly lower in patients with traumatic brain injury (TBI) than in control groups. A significant correlation existed for Aβ-42 levels and outcome of patients. Below a cutoff of 230 pg/mL, the sensitivity of Aβ-42 to discriminate between good outcome (Glasgow Outcome Score 4 and 5) and poor outcome (Glasgow Outcome Score 1 through 3) was 100% at a specificity of 82%. CSF tau levels were significantly higher in patients with TBI than in any control group. In patients with multiple CSF samples collected at various time points between 1 and 32 days after the trauma, tau levels increased early after TBI, peaked in the second week post-trauma, and slowly decreased thereafter. Independent of outcome, all patients had normal tau levels when CSF was collected more than 43 days post-trauma.

Conclusions: Aβ-42 and tau may play a potential role in the pathophysiology of TBI. Furthermore, the results of this study suggest that Aβ-42 may be a supportive early predictor for recovery after severe head injury.