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Functional Cerebral SPECT and PET Imaging
edited by Ronald L. Van Heertum and Ronald S. Tikofsky,
336 pp., Philadelphia, Lippincott Williams & Wilkins, 2000, $159
This book is a timely contribution to the burgeoning field of functional brain imaging. The first part of the book addresses the basic physics and principles of SPECT and PET instrumentation followed by the anatomic landscape of the brain and the current understanding of the function of various regions within the brain. In part II of the book, each chapter is devoted to a disease process where SPECT and PET have made substantial contributions. This book covers imaging, and it delivers on these expectations by devoting the majority of the pages to images rather than text. This primary focus on images to illustrate different patterns in various disease states adds strength to the book, having been revised and expanded to include PET imaging. A large section is devoted to the measurement of blood flow in cerebrovascular diseases, dementia, seizures, and head trauma. This is followed by a chapter on psychiatric disorders, brain tumors, and miscellaneous topics such as Lyme disease, encephalopathy, and tinnitus. A final smattering of receptor binding imaging and activation protocols completes this volume.
The first two chapters introduce the basic imaging principles in a straightforward and intelligible style. Radiation risk is explained well and removes some of the common myths. Various corrections important for quantitative recovery of data are included in the second chapter, and they are a welcome addition to the principles of PET imaging. The statement that “no PET tracer for the imaging of neuronal function has received FDA approval” may have been included when the book went to press. Since March 2000, 18F-fluorodeoxyglucose (18FDG) has been approved for epilepsy and is commercially available in most major cities. …
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