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Abstract
The authors report a 75-year-old woman with atypical sporadic Creutzfeldt–Jakob disease (CJD) characterized by MM1-type prion protein (PrP) (methionine homozygosity at codon 129 in the PrP gene and type-1 protease-resistant PrP) and PrP plaques. This patient is the first case of sporadic CJD with plaque-forming MM1-type PrP, suggesting either a shared prion strain with the plaque-forming subset of dural graft–associated CJD or shared host genetic factors that are unrelated to the PrP genotype.
- Received August 2, 2002.
- Accepted in final form October 11, 2002.
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- Sporadic Creutzfeldt-Jakob disease with MM1-type prion protein and plaques
- Sporadic Creutzfeldt–Jakob disease with MM1-type prion protein and plaques
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