Preventing stroke-related seizures
When should anticonvulsant drugs be started?
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Stroke is the leading cause of epilepsy after age 60.1 Despite the importance of the problem, there are few data on the natural history of stroke-related seizures and no good guideposts to suggest when to initiate anticonvulsant therapy after stroke. Can one identify stroke patients in whom one seizure is enough to justify lifetime anticonvulsant therapy? Does it make a difference whether the seizure occurs at stroke onset or months later? The stakes are high.
Anticonvulsant drugs have many side effects and are often poorly tolerated in elderly patients. Since the risk for further seizures after a single unprovoked seizure is low, most epileptologists suggest starting anticonvulsant therapy only after a second seizure.2 However, for patients who have an unprovoked seizure after brain insult, the risk of a subsequent seizure is almost double that seen in patients with a seizure of unknown cause. Thus, the risk of epilepsy in some patients with …
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