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According to the World Health Organization classification, gliomatosis cerebri (GC) is defined by diffuse neoplastic glial cell infiltration involving at least two lobes of the brain and preserving the underlying neural structures, without individual tumoral mass.1 Because of the diffuse characteristics of the lesion, surgery is often limited to a diagnostic biopsy. Radiotherapy necessarily involves a large volume (most often the whole brain) and results in substantial toxicity. However, a 38-month median survival time has been reported with this treatment and it has been suggested that it may benefit at least some patients.2,3⇓ Up-front chemotherapy has seldom been tested in GC. Recently, …
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