Clinical features and changing patterns of neurodegenerative disorders on Guam, 1997–2000
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To the Editor:
Marianas dementia (MD) was first brought to attention during house-to-house surveys of neurodegenerative disease in southern villages of Guam during 1987 through 1988.1 Lavine et al.1 identified 55 cases of progressive neurodegeneration among 3,579 residents. Thirty-six had ALS or parkinsonism, but 19 cases (35%) had only dementia. Because such a “pure” dementia had not previously been identified as a clinical entity on Guam, Lavine et al.1 coined the term Marianas dementia. They were not certain then whether this was the same dementia that accompanies parkinsonism in the parkinsonism–dementia complex (PDC),2 or a different and separate, age-related dementia of late life.
During 1997 through 2000, Galasko et al.3 used current clinical research methods to evaluate 83 Guamanaian Chamorros with MD and 90 subjects with PDC. …
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