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To the Editor:
I read with interest the report by Boroojerdi et al.1 and its accompanying editorial.2 Boroojerdi et al.1 conclude that repetitive transcranial magnetic stimulation (rTMS) to the left prefrontal cortex (PFC) specifically enhances analogic reasoning. However, their data show improved response time (RT) with stimulation of the left primary motor cortex (M1) as well as with the left PFC. In the case of M1 stimulation, improvement is attributed to a nonspecific effect, although significant effects were not demonstrated in all conditions. One of the references cited provides evidence that stimulation to M1 specifically improves reaction time on more complex tasks.3
The statistical power of the M1 analysis (based on 14 subjects) is greater than that of the left PFC analysis (based on eight subjects). The failure to demonstrate significant RT improvement in the literal condition with left PFC stimulation might simply have been an issue of power. …
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