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Abstract
The authors report an intense downregulation of transforming growth factor-β1 (TGF-β1) serum levels 4 weeks from start of interferon-β1a (IFN-β1a) treatment at 44 μg/week in 271 patients with relapsing–remitting MS, which was still present after 1 year (p < 0.001). In line with previous data, interleukin-10 serum levels did not vary significantly. These results indicate that the immunomodulatory effects of IFN-β might not be restricted to the postulated anti-inflammatory mechanisms and address the role of TGF-β in the pathogenesis of MS.
- Received January 18, 2001.
- Accepted May 1, 2001.
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