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To the Editor:
Mendell et al. report the results of a double-blind placebo-controlled randomized trial of IV immunoglobulin (IVIg) in patients with chronic inflammatory demyelinating polyneuropathy (CIDP).1 I would question the need for such a trial given that prednisone, in a prospective randomized trial,2 and plasmapheresis3,4⇓ and IVIg,5,6⇓ in prospective randomized controlled trials, have each previously been shown to be effective in the treatment of CIDP.
The authors cite a variety of reasons to justify their study. First, many patients enrolled in the prior studies of IVIg had previously received or were receiving other forms of immunomodulatory therapy and so it had not been unequivocally established …
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