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To the Editor:
We read with interest the editorial by Richard and Nutt1 describing worsening of motor function in patients with Parkinson’s disease (PD) after treatment for psychosis induced by antiparkinsonian agents. In their editorial, the authors cite a 1995 article by Rich et al.2 who reported six cases of akinetic–rigid syndromes in psychotic elderly patients treated with risperidone 1 to 4 mg/day. After five patients demonstrated worsening extrapyramidal symptoms (EPS), these authors concluded that some patients with PD tolerate risperidone, while others exhibit worsened motor function.
Findings from our recent study3 differ from those of Rich et al. regarding the risk of EPS in patients …
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